Manic mice turn the clock

Is it too late to turn back the clock?

The esteemed health economist, Gavin Mooney, who died in tragic circumstances in December 2012, devoted his last book The Health of Nations: Towards a New Political Economy to exposing the pernicious effects of neoliberalism on healthcare. He argued compellingly that the consequences of ‘neoliberalism’ – in his usage, the reliance on market mechanisms to address all the needs of a society in th...

A tunable artificial circadian clock in clock-defective mice

Self-sustaining oscillations are essential for diverse physiological functions such as the cell cycle, insulin secretion and circadian rhythms. Synthetic oscillators using biochemical feedback circuits have been generated in cell culture. These synthetic systems provide important insight into design principles for biological oscillators, but have limited similarity to physiological pathways. He...

The rise of the medical McJob: why we should turn the clock back.

To the Framingham data, turn, turn, turn.

Manic Stupor

Mr. AR, a 24-year-old carpenter, was. brought into treatment for first-episode psychiatric illness. According to reports, AR's alteredbehaviour began suddenly, 2 days earlier and comprised hostility towards all and sundry, prolonged spells of shouting and abusiveness, mindless violence, almost total absence of sleep, and refusal of food. There was no past, personal, or family history of signifi...